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Research and evidence

Low levels of B vitamins have been associated with:

  • Depression (1)
  • Anxiety (2)
  • ADHD-related symptoms (3,4)
  • Cognitive decline (5)
  • Brain tissue loss (13)
  • Mild cognitive impairment (6)
  • Alzheimer's disease (7)
  • Vascular dementia (8)

B vitamins support the brain's ability to process and clear internal waste. When levels are low, harmful compounds may accumulate.

Key markers linked to imbalance:

  • Homocysteine (13)
  • Thiolactone / HTL (15)
  • Altered neuronal proteins (14)
  • Reactive oxygen species (16)
  • Oxidative stress markers (17)
  • NF-kB activity (17)
  • IL-6 levels (18)

B vitamin deficiencies are modifiable risk factors, making them a key focus in prevention research.

Research suggests potential benefits:

  • Reduction in homocysteine levels (19)
  • Lower inflammation markers (20,21,25)
  • Reduced brain shrinkage (22)
  • Slower cognitive decline (23)
  • Improved blood-brain barrier function (24)
  • Improved cognitive performance (25)
  • Reduced depression risk (26)